Yeah, I am. I switched over from Longevinex. No way in hell could I afford that dose in Longevinex. Also, I’m no longer convinced that resveratrol loses its ability to activate Sirt1 if it’s not individually packed in nitrogen.

Ugly, it’s moderately hard to say, because it’s all so subjective. I’m sleeping about an hour less a night. The aches in my joints and muscles I used to feel on waking in the morning seem much reduced. Until I’m completely recovered from my bike accident, I’ve been using a stair-stepper for aerobic exercise, and those sessions seem to go easier as well - but that could just be increasing aerobic capacity, which is to be expected.

Bad effects? Again, I’m not sure. I hadn’t really noticed anything, but now I think about it, I have developed some adolescent-style facial acne, and yesterday I had some shooting abdominal pains - though only for a moment or two, and haven’t seen any recurrence since.

Bottom line: I’ve only been on these massive doses for about three weeks. Prior to that, I was taking 100 mg a day of Longevinex - for about thirty days. For the year and a half or so before that, I was taking 20mg of Longevinex a day.

I’d like to see how things are going after about six months. But in general I think I feel better, although it’s hard to point to specifics, and it’s not definite enough to rule out psychosomatic effects.

The dose: 2 Biotiva 500 mg Transmax caps, and 4 Biotiva mixed resveratrol caps providing 250mg each of trans-resveratrol, the rest cis-resveratrol for a total of 2 grams/day trans, and 1 gram cis. I take half in the morning, and half in the evening.

yeah it seems like most people say the effects are “subtle but undeniable.” I’ve been taking one Biotiva 500 mg capsule every morning for 4 months or so. I’ve noticed that I need less sleep and have more endurance. I’ve also noticed sometimes having a slight pain in the abdomen.
Supposedly it is better absorbed into the system with lecithin, so I have it with milk.
Hard-core “users” inject it, so that it doesn’t have to pass through the liver first.

yeah, the only reason I know that is from Ray Kurzweil’s site:

Research suggests taking resveratrol with lecithin can enhance absorption; therefore, if you take a lecithin-derived phosphatidylcholine supplement, we recommend that you take it at the same time as resveratrol to enhance absorption.